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When assessed behaviorally, MCT2-downregulated animals were impaired in a textured object recognition task, while a similar proportion of MCT4-downregulated animals (about half) showed an identical deficit, mirroring the bifurcation observed in the neurovascular responses

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found that HIF-1 is associated with the acute hypoxic response, while HIF-2 is linked to the chronic hypoxic response

J Biol Chem (2016) 291(33):1730318