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Cells 9, 1849

The choline metabolite, betaine, can also provide a methyl group for the conversion of homocysteine to methionine

J Ethnopharmacol 124:98102 Park M, Kim S (2015) A modern clinical approach of the traditional Korean saamacupuncture

If the cryptic site falls in an N-terminal or C-terminal disordered tail (or in a large flexible linker), trimming the construct boundaries removes the problem entirely