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Abstract Parkinsons disease (PD), the second most prevalent neurodegenerative disorder globally, imposes substantial healthcare burdens on aging populations

Kettenmann H, Ransom BR (2012) Neuroglia

Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism

That separation is clinically documented and is the reason researchers continue to study this molecule despite the commercial development programme ending in 2007