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Alterations in aerobic metabolism have been reported in fibroblasts involved in pulmonary fibrosis [166], particularly increased glycolysis, resistance to apoptosis, and propensity to develop a metabolic-driven fibrotic phenotype, which appears to be linked to decreased ATP synthesis and increased mtROS production [169, 170]

Indeed, data from a meta-analysis included randomized-controlled trials from 1985 to 2015, including 287,304 participants demonstrated that a diet containing tocopherols and tocotrienols is negatively linked to cardiovascular mortality risk (Schwingshackl et al., 2017)

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From genomic modeling to pathway modeling to network biology in breast cancer, AI-based biomarker research from pathological slides, prognostic research, target screening, drug repurposing in drug discovery research in breast cancer, computational methods have completely changed the research in breast cancer