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According to Shuja et al 11 in his study, plasma GSH levels in melasma patients decreased significantly compared to controls and are thought to be a risk factor in the severity of melasma

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Reese G, Viebranz J, Leong-Kee SM, Plante M, Lauer I, Randow S et al (2005) Reduced allergenic potency of VR9-1, a mutant of the major shrimp allergen Pen a 1 (Tropomyosin)1

Practical translational barriers include GMP-scale manufacturability, shelf-life stability under real-world storage, cost-of-goods and pricing, and consumer acceptability (sensory attributes, pill burden, dosing frequency)