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The role of hypoxia-inducible factor isoforms in breast cancer and perspectives on their inhibition in therapy

(2014) 48:S346

Michaux, G., Shafaq-Zadah, M., Brocard, L

Silencing of miR122 has been shown to upregulate CAT-1 ( SLC7A1 ) expression, and subsequently increase arginine uptake to maintain large intracellular arginine pools for nitric oxide (NO) synthesis, resulting in increased resistance to the multi-kinase inhibitor sorafenib (Kishikawa et al., 2015)