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In vitro and in vivo studies in animals have shown that the use of deuterated PUFAs can lower the peroxidation effects on producing atherosclerosis, control hyperlipidaemia, and reduce cholesterol levels in blood ( Although these are beneficial signals for human health, many questions are raised for the whole of the organisms health since the deuterated lipids will accumulate in a vast number of cells and in their membranes, as in the case of myelin, and will cause a significant alteration in the metabolism of the deuterated host organism (Torres et al., 2021)

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In our study, we systematically demonstrated that ACTL6A inhibited GC cell ferroptosis by promoting GSH synthesis through upregulating GCLC