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Samples were then transferred to a clear 96-well plate and the reaction was started by adding assay buffer with GSH reaction mixture (containing NADP+, glucose-6-phosphate, glucose-6-phosphate dehydrogenase, glutathione reductase and Ellmans reagent)

Moreover, this synthetic lethality is particularly pronounced in BRCA-deficient tumors, where HR is already compromised

This allows clinicians to extend dosing intervals , reducing the treatment burden and improving patient adherence

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Affinity Water's region is deemed as being in serious water stress, meaning they are permitted to meter domestic properties