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In patients with genetic disorders that affect Mn homeostasis, insufficient Mn levels can impair enzyme activity by limiting the availability of this essential catalytic cofactor, leading to impaired biological processes, immune dysfunction, and developmental delays 16

Sun C, editor

Anal Biochem 411:223229 Zawada JF, Yin G, Steiner AR, Yang J, Naresh A, Roy SM, Gold DS, Heinsohn HG, Murray CJ (2011) Microscale to manufacturing scale-up of cell-free cytokine productiona new approach for shortening protein production development timelines