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Size does not determine alone the fate of nanocarriers, the same permeability values were measured for polystyrene nanoparticles with 100, 200 or 400 nm diameter across a microfluidic BBB model [59]

DOI: Published: Publisher Name: Springer, Berlin, Heidelberg Print ISBN: 978-3-642-30017-2 Online ISBN: 978-3-642-30018-9 eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences

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3 Anticancer mechanisms of functional food active ingredients 3.1 Anticancer mechanisms of polyphenols 3.1.1 Antioxidant and anti-inflammatory effects Polyphenolic compounds exhibit significant antioxidant and anti-inflammatory activities, scavenging excess free radicals and reducing cellular damage caused by oxidative stress ( 3.1.2 Apoptosis and autophagy regulation Polyphenols induce programmed cell death in cancer cells, mainly via mitochondria-mediated endogenous pathways