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Taking tirzepatide a day early is generally acceptable as long as you maintain roughly seven-day intervals going forward

Nayyef et al

Acknowledgements All schematic figures were created using BioRender

The top of the stalk domains of this Ta OGA cryo-EM structure are in the same tight arrangement as in the hOGA catalytic core crystal structures, whereas one of the Ta OGA catalytic domains rotates away from the neighbouring stalk domain, which is reflected in a pairwise inter-C distance of 33 in Ta OGA (Lys59) and 40 in hOGA (Val113) (Fig