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Your choice of binding buffer will influence the binding capacity of the beads , so if you are capturing substantially less than 8 mg of protein per mL of resin, and your protein isnt really big, then it is worth considering if your binding buffer is limiting the capture efficiency of the beads

2008 Sep 15;64(6):468-75

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Possible adverse events include hypocalcemia, metabolic alkalosis (elevated blood pH), hypernatremia (elevated sodium), fluid overload, worsening hypertension, and heart failure