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Description

Redox Signal

While some variants, such as some H1 variants, are regulated in a similar manner to the core histones, the transcriptional and translational regulation of most variants is more typical of other genes in the genome

In lung cancer, the loss of BRG1 or BRM components of the SWI/SNF chromatin remodeling complex activates the NRF2 signaling pathway, particularly increasing the expression of NRF2 target genes HMOX1 and GSTM4