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Safety Measurements Any adverse event during the course of the study was monitored and reported to the study staff at week 6 (visit 5) or week 12 (visit 8) in the clinic or directly to the principal investigator throughout the study

The fate of serine metabolism on macrophage polarization was investigated and a novel mechanism was proposed by which serine deficiency stimulates the M1 phenotype and inhibits STAT6-mediated M2 polarization by activating p38-dependent JAKSTAT-1 axis [286], suggesting that serine metabolism may be an underlying target

ImageStream analysis Cells were loaded into an Amnis ImageStreamX Mark II system (EMD Millipore) for imaging and fluorescence detection

Helps keep skin moisturized and naturally radiant.

Cultures were left to express protein for 1620 h