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Xenobiotic and Oxidative Stress Protection Beyond Estrogen GSTM1 and GSTT1 are not estrogen-specific enzymes they are broad-spectrum detoxification proteins that process a wide range of electrophilic and oxidative substrates

Although the downregulation of Gpx3 by pefloxacin was not observed, Achilles tendons from rats treated with only dexamethasone or with both pefloxacin and dexamethasone showed significantly higher gene expression levels of Gpx3 than those from vehicle-treated or pefloxacin-treated rats (Figure 5D)

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So, if enterocyte zinc concentration is high, then MTs can bind to intracellular zinc and reduce free zinc ions [120, 121]