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Neither ADPR-Ub nor PR-Ub can be used in canonical ubiquitination reactions 7 , and their accumulation may interfere with key signaling cascades in infected cells and ultimately impede bacterial replication

51 Even though the same mutations seem to drive the growth of primary and metastatic cancers, the efficiency with which a particular clone seeds metastasis might still depend on its mutations

A limitation of the study was the small sample size and the lack of investigation into whether CAL02s efficacy is concentration-dependent

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