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A 2021 review of NNMT as a metabolic target stated plainly that clinical trials targeting NNMT have not been reported until now (Liu 2021, PMID 34368359) [5], and that held into 2026

Wolffenbuttel BHR, Heiner-Fokkema MR, Green R, Gans ROB

additionally, more research is required to investigate differences between NAD + modulators within different tissues, different models or pathologies, administration or exercise regimens, and how to successfully translate these findings to humans, while several clinical trials have already been conducted

Response rates were correspondingly lower: 66% of Contrave patients achieved 5% weight loss, and 36% reached 10% weight loss

Tesamorelin is a prescription compound and an FDA-approved therapeutic, available only to qualified licensed medical professionals