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Abatacept is the only T cell co-stimulation modulator approved thus far for the treatment of moderate-to-severe RA (Schiff, 2015)

The FDAs approval, which is for both subcutaneous and intravenous formulations of Otulfi, was backed by a thorough evaluation of a comprehensive data package, which included analytical, preclinical, clinical and manufacturing data, according to the companies

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doi:10.1007/s00128-008-9558-7 Friedmann D, Mendive C, Bahnemann D (2010) TiO2 for water treatment: parameters affecting the kinetics and mechanisms of photocatalysis