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Complexity in Patient Understanding and Compliance: Many patients struggle with foundational aspects of melasma treatment, such as effective photoprotection, proper sunscreen use, and understanding radiation sources like blue light, HEV, and infrared

Furthermore, it is usually linked to other mental diseases, such as mood disorders and substance use disorders (Barth, 2021)

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Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype