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Collagen fibers are thicker and coarser in the inner dermal layer than in the outer layer, with thinner and more tenuous collagen fibers (68)

YanRZhangPShenSZengYWangTChenZet alCarnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion

After treatment, cells were fixed in 4% paraformaldehyde for 5 min followed by permeabilization with 0.1% saponin in 3% BSA for 30 min

Obviously, a growing body of preclinical evidences suggests that the induction of lipid peroxidation by inhibiting system x c - might be an effective therapeutic strategy to clear cancer cells and prevent the acquired resistance to several cancer drugs, such as lapatinib, dabrafenib and vemurafenib (Table S1) [228, 261, 262]

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