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Ascorbic acid (100 M) has been shown to modify both of the above systems (Figure 2)

Acknowledgments The authors thank to the editors and reviewers for their hard work and important comments

Cycles under 8 weeks rarely yield meaningful data

10.1016/j.bcp.2019.04.008 35 GebhardtR

Intracellular levels of L-lactate contribute to the production of pro-inflammatory cytokines in FLS through intracellular signaling that involve the MAPK and NF-B pathways (133)