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These compounds inhibited both monophenolase and diphenolase activities with an irreversible inhibition manner

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Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1

It activates a variety of downstream target proteins that regulate cellular functions, and malfunctions in its activation are associated with the onset of a variety of diseases, including cancer, inflammation, metabolic disease, and cardiovascular disease