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There was no statistically significant improvement in MS during the 24-week treatment period in cohort 1 (rate of change = 0.05 dB/month, 95% CI: 0.07 to 0.17, P = 0.38) or cohort 2 (rate of change = 0.04 dB/month, 95% CI: 0.08 to 0.16 dB/month, P = 0.48), but in cohort 3, there was a statistically significant improvement in MS of 0.15 dB/month (95% CI: 0.040.26