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In mice, treatment for PCa with pomegranate extract was successful

Labb, K

doi: 10.1016/j.applanim.2019.104853 63 RudarM.NaberhuisJ

And when it comes to a sophisticated peptide like IGF-1 LR3, the stakes are even higher

Thus, activated by IGF-1R, PI3K phosphorylates PIP2 to produce PIP3, which recruits AKT to the plasma membrane, where it is phosphorylated and activated (49)