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The transmembrane protease-activated receptor 2 (PAR-2), which is expressed on keratinocytes and has an important role in the formation of melanocyte dendrites and the phagocytosis of melanosomes by keratinocytes [129, 130], could also be specifically blocked by compounds to decrease epidermal pigmentation [131]

To date, these patients remain alive and under follow-up, with no recorded local recurrence or disease progression after a median follow-up period of 61 months

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To mimic in-vitro responses observed in the organ chamber, where we stimulated Ach-dependent vasorelaxation in the presence or absence of TMAO pre-incubation, HAECs were pre-incubated for one hour with TMAO (10 6 M) followed by one hour stimulation with Ach (10 6 M)

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