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BMJ Open 11, e047632

The enterocyte lining of the GI tract contains one of the most rapidly reproducing cells of the human body, and depletion of this protein can result in continued disruption of intestinal integrity

21 The focus of this review is to outline therapeutic strategies that have previously been developed and tested, agents that are currently being tested in clinical trials and future therapies that extrapolate from the latest published basic research in the laboratory for the treatment of the most common NF1-related tumours, including cNFs, pNFs, MPNSTs and OPGs