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Most researchers report no noticeable potency issues at the 5-week mark, but conservative protocols suggest using the vial within 4 weeks and discarding any remainder

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Quantitative analysis of collagen development as well as granulation tissue formation and angiogenesis was performed in vivo models, incisional skin wounds, coloncolon anastomoses, and synthetic sponge implants (Seiwerth et al., 1997)