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To Spraque-dawley mice short-term give big dose dextran iron (100 mg/kg of iron 7 days), liver of animals to dissect histologic study, found in the liver cells appear in the iron deposition, but did not see the damage to the liver cells

Infect Immun 76:12891297

Cases of manganism the majority of which are caused primarily by the inhalation of airborne Mn have been widely documented globally among miners, dry-cell battery factory workers, smelters, and welders 146,147

the macrophage plays a key role in immune function by engulfing foreign particles and organisms which are then carried to regional lymph nodes where the information is used to stimulate either T cell or B cell responses

Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation