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Comorbidity: Substance use disorders and other mental illnesses

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Adverse drug reactions to DEX are primarily dose-dependent and mainly involve cardiovascular effects such as sinus bradycardia and mild hypotension, particularly during TH or following bolus administration (241243, 248)

This work was supported by Innovation Project of Guangxi Graduate Education of GXUCM (YCSW2024413), the National Natural Sciences Foundation of China (81860539), and Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica (20-065-38)

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