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Additionally, vine tea total flavonoids (TFs) activate the AMPK/mTOR pathway to induce autophagy and modulate lipid metabolism-related proteins in HFD-fed mice, reducing de novo lipogenesis and regulating glycerophospholipid metabolism

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Funding This study was supported by grants from the Joint Innovation Team for Clinical & Basic Research (202401-06) and the Academic Promotion Program of Shandong First Medical University(092-200012 PL)

Abstract Cellular senescence, driven by the interaction between FOXO4 and p53, is increasingly recognized as a crucial mechanism in brain aging and the development of neurodegenerative disorders