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Vascular Pharmacology , 113, 6475

Inhibition of these cardiac AC isoforms by Ca 2+ , which their own cAMP generation permits to enter the cardiomyocyte, serves as a form of feedback control regulating pacemaker rhythmicity as well as the force of contraction (Mou et al., 2009)

Assuming the same density for the two phases, c and h , the mass balance equation can be written for each phase: where is the mass exchange rate between each phase and ( c , n ) = ( h , n )

Continued development of modified derivatives and nanoparticle-based systems may help overcome these hurdles

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