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By diminishing the expression of LTA 4 H, the intermediate lipid metabolite LTA 4 is prevented from being metabolised to the more pro-inflammatory eicosanoid LTB 4 , and preserved for the biosynthesis of resolving eicosanoids, such as LXA 4

For energy purposes, twice weekly is sufficient

3 Clinical Outcomes in ALS The US Food and Drug Administration (FDA) provides guidance on important outcomes in ALS clinical trials, such as mortality, functional status, respiratory and strength measures, and patient-reported outcomes [27]