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In addition, berberine can also regulate liver TG synthesis and hepatic steatosis through the activation of AMPK-SREBP-1c-SCD1 pathway both in HFD mice and in HepG2/ AML12 cells exposed to high glucose and palmitic acid [125]

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4547 This complex induces mitochondrial dysfunction through caspase-8-dependent cleavage of Bid

This can contribute to dysbiosis and intestinal permeability as undigested foods are a) inflammatory to the lining of the small intestine and b) serve as food for pathogenic microbes