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The most substantial body of human-adjacent research involves early-phase trials for inflammatory bowel disease conducted by the Croatian pharmaceutical company PLIVA in the 2000s which have never been published in indexed, peer-reviewed journals

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The authors suggested that this would lead to increased pools of methylated thiopurine metabolites, which might inhibit de novo purine synthesis and, thus, lead to lower levels of endogenous purines to compete with 6-TGN to be incorporated into DNA

The benefits of NAD therapy include: Increased energy: NAD therapy can help to increase energy levels by improving cellular function and reducing oxidative stress