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doi: 10.1006/bbrc.1998.9729 23 ZavadskisSWeidingerAHanetsederDBanerjeeASchneiderCWolbankSet al

Adenosylcobalamin is the mandatory cofactor for the enzyme methylmalonyl-CoA mutase (MCM)

Published in vitro work has characterized 5-Amino-1MQ as a competitive NNMT inhibitor with low micromolar potency against the recombinant enzyme, and as a cell-permeable agent that suppresses NNMT activity in cultured 3T3-L1 adipocytes at micromolar concentrations [1]