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Additionally, aged fibroblasts often have underdeveloped endoplasmic reticulum and diminished secretory activity due to a reduction in the biosynthetic machinery

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Nonetheless, -KG competitors (DM-succinate and ITA) inhibit the YBX1AMPK axis in both cancer cells and 293T cells, suggesting that -KG availability may broadly determines energy sensing in human cells

doi: 10.1016/j.trecan.2018.03.004

Undersea Hyperb Med, 22,1,pp.17-22