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The progression of fibrosis is mainly driven by mesenchymal cells of the intestine (fibroblasts, myofibroblasts, and smooth muscle cells), which are contributing to the extracellular matrix (ECM) and crosslinking enzymes production

These results from both transcriptomic analysis and qRT-PCR indicated that the combination of (-)-Vestitol and Salviolone synergistically regulated the expression of the Glp1r , Htr4 , Ntsr1 , Nos1 , and Ntrk1 genes within the Neuroactive ligand-receptor interaction and Calcium signaling pathway

More striking still, the majority of participants on the higher doses reached normal liver fat a "resolution" of steatosis by week 24, which no one on placebo achieved

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