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Abstract Neurodegenerative disorders represent a growing global health burden and remain largely incurable, with current therapies providing only symptomatic relief and limited disease modifications

Open label studies demonstrated that fetal mesDA neurons transplantation into the striatum of PD patients had potential for clinical improvement as well as graft survival and function, as assessed by clinical measures, neuroimaging (Brundin et al

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Despite their specificity and efficacy, ligands production and conjugation are expensive, especially for the complex design of delivered therapeutics 229