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In this section, we mainly review and discuss pharmacotherapies based on pathological features and signal transduction mechanisms (Fig

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Retatrutide (CAS 2381089-83-2) is a triple-agonist peptide that engages three receptors simultaneously the glucose-dependent insulinotropic polypeptide (GIP) receptor, the glucagon-like peptide-1 (GLP-1) receptor, and the glucagon receptor making it one of the most-studied multi-receptor metabolic peptides currently in the research literature