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Accumulation of intermediates such as succinate and fumarate can act as metabolic signals that stabilize hypoxia-inducible factor 1 (HIF-1) and amplify inflammatory cytokine production, thus coupling mitochondrial dysfunction to inflammation 112,113

A proof-of-concept study in 51 patients with chronic neuropathic pain, including 35 with CIPN, demonstrated that 82% had improvement in patient-reported measures of pain, mood, and activity levels (Fallon 2015)

Author contributions XM: Methodology, Formal Analysis, Software, Writingoriginal draft, Funding acquisition

And what you mentioned earlier about you guys all having meetings and actually going through each person who walks through the door, I dont feel like thats done a lot