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Any alterations in the one-carbon cycle can, therefore, alter the genome methylation and influence the expression of vital genes involved in key mechanisms like angiogenesis, glucose metabolism, lipid metabolism, and neurodevelopment that will program the foetus for diseases in later life. 3 These diseases may result from: Impaired DNA synthesis and repair Changes in methylation that negatively change gene expression If there is a mutated MTHFR gene, the availability of active methyl folate is decreased

Long CJ, Chu DI, Tenney RW, Morris AR, Weiss DA, Shukla AR, Srinivasan AK, Zderic SA, Kolon TF, Canning DA (2017) Intermediate-Term Followup of Proximal Hypospadias Repair Reveals High Complication Rate

3eg), demonstrating that dHTC1 activity is dependent on its ability to cooperatively engage CRBN