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Important safety warnings seek urgent medical attention if you experience: Severe or persistent abdominal pain, which may radiate to the back this could indicate pancreatitis , a serious but rare risk associated with GLP-1based therapies as a class [16] [17] Right upper quadrant pain, fever, or jaundice these may suggest gallbladder disease , another class-associated risk Signs of dehydration (dizziness, reduced urine output, extreme thirst) resulting from severe vomiting or diarrhoea, which can affect kidney function Pregnancy and breastfeeding: Use of GLP-1based therapies and related investigational agents is not recommended during pregnancy or breastfeeding

doi: 10.1086/340042

2023 Feb 28;14(1):e0237022

2.4 Genetic factors Genetic alterations and associated changes may significantly impact the rise of MDR

Advanced glycation end-products (AGEs) create abnormal cross-links that stiffen collagen fibers, reducing their ability to support smooth skin and increasing brittleness that leads to deeper wrinkle formation