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OCT4/SOX2 can bind to the promoter region of integrin 6 (also known as CD49f or ITGA6) and enhance its expression, and integrin 6 promotes multipotency and stemness in MSCs through the PI3K/AKT/p53 pathway (Yu et al., 2012)

Such cases can result from inflammation, degenerative diseases, or autoimmune diseases

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