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Going to bed with a full stomach (water or food) makes nighttime reflux more likely, and overnight reflux is the version most associated with Barretts esophagus and other complications

omega-3s from fish oil are best delivered as softgels, which wouldn't work as well for the other two ingredients

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Given that the status of these micronutrients in patients with T2DM is already likely to be suboptimal and that these deficiencies are variously associated with diabetic complications such as compromised endothelial, microvascular, vascular and neurological function, 38,43,4649,80,85,9597 it may be appropriate to consider supplementation where appropriate to mitigate these negative impacts of metformin

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