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The rise in intracellular calcium triggers the activation of calcium/calmodulin dependent protein kinase II (CaMKII), which releases large amounts of calcium from the sarcoplasmic reticulum calcium pool into the cytoplasm, causing calcium overload

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The most commonly reported adverse effects include mild nausea (8-12% of users), temporary digestive upset (5-8%), and occasional headaches (3-5%)

Sergeeva, L

[80] [82] Animal-derived food sources with a high concentration of vitamin B 12 include liver and other organ meats from lamb, veal, beef, and turkey