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In contrast the findings for glutamine were inconsistent with two studies reporting no significant difference in serum glutamine in children with autistic disorder compared with controls [69, 89], a later study reporting a significant decrease in platelet glutamine in children with autistic disorder [68] and further studies that reported serum glutamate to be significantly higher in adults with autistic disorder [75] and children with autism spectrum disorders (mixed diagnoses) than controls [87]

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In the lipid-rich environment of the CNS, ferroptosis could therefore play a significant role in secondary damage, the neuron-astrocyte interaction is also critical for maintaining brain lipid metabolism, indicating that neurons may be more sensitive to drastic changes in lipid peroxidation, moreover, lipid peroxidation contributes to secondary damage after SCI and highlights the possible use of lipid metabolism regulator to treat SCI [46,47,48]

Effects of micronutritional status on other patient related parameters such as quality of life still have to be evaluated