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The differences between CGRP medications There are two types of CGRP inhibitors: CGRP monoclonal antibodies (MABs), which are used for migraine prevention: Erenumab (Aimovig) Fremanezumab (Ajovy) Galcanezumab (Emgality) Eptinezumab (Vyepti) CGRP receptor antagonists (gepants), which are used both as abortive and/or preventive migraine medications Rimegepant (Nurtec): Acute or preventive treatment of episodic migraine Atogepant (Aquipta): Preventive treatment - TGA approved but not yet available in Australia Ubrogepant (Ubrelvy): Acute treatment - not yet available in Australia Zavegepant (Zavzpret): Acute treatment - not yet available in Australia Like most new medicines, accessing the CGRP treatments privately is expensive

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Pandey P, Kumar A, Pushpam D, Khurana S, Malik PS, Gogia A, Arunmozhimaran E, Singh MB, Chandran DS, Batra A (2023) Randomized double-blind, placebo-controlled study of oral gabapentin for prevention of neuropathy in patients receiving paclitaxel

It is directed by the glutathione antioxidant system, which is formed by GSH, glutathione peroxidase (GPX), and glutaredoxin (GRX) but most importantly it can effectively prevent ROS overproduction [79]

It is important to note that depressive symptoms themselves may reduce medication adherence, highlighting the need for clinicians to closely monitor and intervene promptly when depressive symptoms occur in PLWH