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While we cannot rule out that the curtailment of protein synthesis is more effective when targeting ribosome biogenesis instead of translation, the former will additionally reduce cellular ATP consumption by blocking ribosome assembly and restricting pre-rRNA synthesis and processing 4,5,29

The dose stays consistent while the frequency decreases, followed by 48 weeks off

This process generates pyruvate and glutamate, which are then utilized in liver gluconeogenesis [42, 43], thereby maintaining the delicate balance of amino acid metabolism and energy production

We associated this with increased levels of electrons in mitochondrial electron-transport chain (ETC) under hypoxia as a result of limited access to molecular oxygen

In it, a -barrel made up of eight antiparallel -strands organized in a Greek key pattern makes up each subunit [45] with three external loops