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Methods: Patients with cirrhosis were screened on transthoracic echocardiography (TTE) with tissue Doppler imaging for presence of LVDD, and those with ischemic heart disease, pacemaker in situ or known arrhythmia, prior use of beta blocker, valvular heart disease, anemia, uncorrected thyroid dysfunction, and hepatocellular carcinoma were excluded

38,39 However, the Wnt/-catenin signalling pathway is not only positively activated by the above factors but also inhibited by many negative feedback regulators, such as Notum, Tiki, DKKs, Wise/SOST, IGFBP-4, sFRPs, WIF1, and ZNRF3/RNF43

Sci Total Environ 626:971981

The treatment lasted for four weeks, after which cardiovascular outcomes were assessed

Concurrently, GPX4the sole enzyme responsible for repairing membrane lipid peroxidationloses activity when its cofactor GSH is depleted, such as through inhibition of the cystine-glutamate antiporter System Xc (SLC7A11/SLC3A2), leading to irreversible lipid peroxide (LPO) accumulation 23