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These hormones are part of a complex feedback loop that involves stimulation of the adrenal gland by the pituitary hormone ACTH (adrenocorticotropic hormone)

This transformation allows the crystals to act as dams that are recognized by the innate immune system, triggering a robust inflammatory response (102)

For many years, GSSG was thought to be the prime source of oxidative equivalents for the protein disulfide formation, but starting from twenty years ago the endoplasmic reticulum oxidase (Ero1) and the protein disulfide isomerase (PDI) were indicated as the true actors in this oxidative mechanism 6,7,8